Aralen

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aralen

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Aralen is an aminoquinoline which used to treat or prevent malaria infections and a certain type of parasitic infection. In addition, there is a study showing that Chloroquine was effective against the new coronavirus, 2019-nCoV, at least in test tubes.

Table of contents

You can order Aralen 250mg or 500mg pills through our online pharmacy, which brings cost savings and convenience. Aralen, also recognized by its generic name Chloroquine, is an antimalarial medication. It has also been explored for its antiviral properties, particularly for certain viral infections. This medication works by carefully interfering with how specific pathogens reproduce, offering a focused way to treat them. Understanding how it works and how to use it correctly is very important if you are considering this treatment option.

Aralen Overview
Active Ingredient Chloroquine (as Chloroquine Phosphate)
Drug Class Antimalarial, Disease-Modifying Antirheumatic Drug (DMARD)
Primary Uses Malaria treatment and prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus
Available Forms Oral tablet (pill)
Typical Strength(s) 250mg, 500mg (referring to Chloroquine Phosphate)
Regulatory Status Prescription (Rx)
Administration Oral
Onset of Action Varies by indication, generally hours to days
Duration Up to several days post-dose due to long half-life
Manufacturer Sanofi (historically), now various generics

How Chloroquine Works: A Trusted Treatment

Aralen contains the active ingredient Chloroquine. This medication has a long history, primarily used as an antimalarial drug. It was developed during World War II, and quickly became a key medication due to its effectiveness against various Malaria strains. Beyond malaria, Chloroquine has also been recognized for its anti-inflammatory and immunomodulatory properties. This led to its use in treating autoimmune conditions like Rheumatoid Arthritis and Systemic Lupus Erythematosus. While its main uses are well-understood, there has been much interest and research into its possible antiviral abilities, especially during specific global health crises. In Canada, this medication requires a prescription, meaning a healthcare professional must guide its use.

The Science Behind How Chloroquine Helps

Aralen (Chloroquine) works in several ways, contributing to its many therapeutic uses. For malaria, it gathers inside the acidic spaces of the malaria parasite (Plasmodium species) found in red blood cells. In these spaces, Chloroquine stops heme polymerization, which is a vital way the parasite gets rid of toxins. This disruption causes toxic heme to build up, effectively killing the parasite and clearing the infection.

For autoimmune diseases, Chloroquine helps by affecting immune responses. It interferes with how antigens are presented, how lysosomes work, and it reduces the production of inflammatory cytokines. When considering its potential antiviral effects, Chloroquine is thought to increase the pH inside endosomes and lysosomes. This then stops certain viruses, which need an acidic environment to enter and spread, from replicating.

After you take it by mouth, Chloroquine is well-absorbed and spreads widely throughout your body, accumulating in various tissues. Its effect concerning malaria symptoms can be quite fast, often within hours, but the full treatment benefit might take a few days. You might find it reassuring to know that Chloroquine stays in the body for a long time due to its extended elimination half-life. This means its helpful effects last longer, but it also highlights the importance of careful management to prevent any build-up that could lead to side effects. Your body primarily processes Chloroquine in the liver, and both the drug and its byproducts are mostly removed through the kidneys.

Important Uses for Aralen

Aralen's main clinical uses are centered around its ability to fight malaria and reduce inflammation. For malaria, Chloroquine is a crucial medication for treating and preventing infections caused by Chloroquine-sensitive Plasmodium vivax, P. ovale, and P. malariae species. It effectively removes these parasites from your bloodstream, helping to relieve Fever and other symptoms. Using it to prevent malaria is especially valuable for travelers going to areas where Chloroquine resistance is not widespread.

Beyond malaria, Chloroquine is very important in rheumatology. For people with rheumatoid arthritis, it acts as a disease-modifying antirheumatic drug (DMARD). It works to lessen inflammation, Pain, and joint damage. Doctors often consider it for patients with mild to moderate disease, and it can be used alone or with other DMARDs. Similarly, for systemic lupus erythematosus, Chloroquine helps manage symptoms like skin lesions, joint pain, and tiredness. It does this by adjusting the immune responses that contribute to the disease. Its anti-inflammatory effects make it a good choice for long-term management of these chronic autoimmune conditions, often providing benefits over several months of consistent use. While there has been research into its potential antiviral uses for certain conditions, these are considered "off-label" uses and are usually reserved for specific clinical situations under strict medical supervision, as its effectiveness and safety for these uses are still being fully understood.

Who Can Use Aralen and What to Consider

Aralen (Chloroquine) is suitable for specific patients. These are mainly those diagnosed with Chloroquine-sensitive malaria or certain autoimmune conditions like rheumatoid arthritis or systemic lupus erythematosus. For malaria treatment or prevention, patients traveling to or living in areas with Chloroquine-sensitive strains are ideal candidates. For autoimmune diseases, individuals experiencing inflammatory symptoms that haven't responded to initial treatments, or those looking for a milder DMARD in their treatment plan, might benefit.

However, certain groups of patients need careful consideration. Pregnant women should only use Chloroquine if the potential benefits are clearly greater than the risks, especially for Malaria Prevention where the risk of the disease itself might be higher than the drug's risks. Nursing mothers should also talk to their healthcare provider since Chloroquine does pass into breast milk. Elderly patients might need dose adjustments because their kidney function could be reduced. This could affect how the drug is cleared from their body and might increase the chance of side effects. Children can be prescribed Chloroquine, with dosing based on their weight, which is vital for safety and effectiveness.

You should not use Chloroquine if you are allergic to it or similar compounds. Also, if you already have existing retinal or vision changes, you should avoid it, as Chloroquine can make these conditions worse. Patients with porphyria or Psoriasis should also use Chloroquine with caution, as it can worsen these conditions. It's essential to have a thorough medical history taken and an eye examination before starting Chloroquine, especially if you plan to use it long-term.

How to Take Aralen Effectively

Taking Aralen (Chloroquine) correctly involves more than just following dosage instructions; it means using strategies to get the most benefit and reduce potential side effects. For preventing malaria, taking the medication on the same day each week is important. You should start one to two weeks before you travel, continue throughout your stay, and keep taking it for four weeks after you leave the area where malaria is a risk. This helps maintain steady protective levels in your blood. This consistent timing is vital because Chloroquine stays in your body for a long time.

Administering the pill with food or milk can significantly help reduce stomach upset, which can be a common side effect at the beginning. If you miss a dose for prevention, take it as soon as you remember. However, if it’s almost time for your next dose, it's generally better to skip the missed dose and just continue your regular schedule, avoiding taking a double dose.

For long-term conditions like rheumatoid arthritis or lupus, it's extremely important to follow your prescribed daily or weekly plan. The helpful effects build up over time. It's common for patients not to feel much relief for several weeks or even months. Understanding that it takes time for the medication to work can help manage your expectations and encourage you to stick with your treatment. Storing Aralen in its original container at room temperature, away from moisture and direct light, helps keep it stable. When traveling, especially to areas where malaria is common, it's a good idea to keep your medication easily accessible and protected from extreme temperatures. You should also know that Chloroquine can make the effects of certain other medications stronger, so a complete review of all your medications with your healthcare provider is very important.

Understanding and Managing Potential Side Effects with Aralen

When taking Aralen (Chloroquine), knowing why common side effects happen can help you manage them more effectively. Many initial side effects, like feeling sick to your stomach, vomiting, stomach cramps, and Headache, are often due to your body adjusting to the medication. Taking Aralen with food or milk can greatly help reduce stomach discomfort. These symptoms are usually mild and temporary, often fading as you continue treatment.

While less common, more serious side effects need immediate medical attention. With long-term use or high doses, Chloroquine can affect your eyes, potentially causing retinal damage. This is why regular eye examinations, including visual field testing, are crucial if you are on this therapy for an extended period. If you notice any changes in your vision, blurry sight, or difficulty seeing at night, you should report these right away. Other serious concerns include heart effects like an irregular heart rhythm, especially if you already have heart conditions. Signs like palpitations, dizziness, or fainting require prompt evaluation. Though rare, Chloroquine can also affect your bone marrow, potentially leading to anemia or a low white blood cell count. Unusual bleeding, bruising, or signs of infection should prompt a medical consultation. Understanding that these effects might be linked to the drug's accumulation and how it works allows for proactive monitoring and intervention. This helps ensure that the benefits of your treatment outweigh any potential risks.

What is the maximum duration I can take Aralen for malaria prevention?

For malaria prevention, you typically take Aralen for the entire time you are in a malaria-risk area and then continue for four weeks after leaving that area. There might be special situations where you could take it longer, but a healthcare professional should always determine this based on your travel history and individual health needs.

Can Aralen affect my vision long-term?

Yes, using Aralen for a long time or at high doses can potentially lead to permanent retinal damage. This is why regular eye exams, including specific tests like visual field assessments, are strongly recommended for patients on extended therapy. These exams allow for early detection and intervention if any changes occur, which is very reassuring.

Does Aralen interact with other medications?

Chloroquine can interact with several medications, including antacids (which can reduce its absorption), certain heart medications, and some Antibiotics. It's crucial to inform your doctor and our pharmacy service about all medications you are currently taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions. Please feel free to discuss any concerns you have.

How quickly will I feel relief from rheumatoid arthritis symptoms with Aralen?

Unlike some other medications, Aralen's effects on autoimmune conditions like rheumatoid arthritis are not immediate. It typically takes several weeks to months of consistent use (often from 3 to 6 months) for you to experience significant improvement in your symptoms. Patience and sticking to your prescribed plan are key during this time.

Is Aralen effective against all types of malaria?

No, Aralen is only effective against Chloroquine-sensitive strains of malaria, mainly Plasmodium vivax, P. ovale, and P. malariae. Many regions globally have widespread Chloroquine-resistant Plasmodium falciparum, for which other antimalarial medications would be necessary. Your healthcare provider will assess the resistance patterns in your travel destination to recommend the most appropriate prevention for you.

Can I drink alcohol while taking Aralen?

Moderate alcohol consumption is generally not strictly forbidden with Aralen. However, drinking too much alcohol can increase the risk of liver-related side effects and might make stomach upset worse. It's always best to discuss your alcohol consumption habits with your doctor to ensure your safety and comfort.

What should I do if I experience sun sensitivity while on Aralen?

Chloroquine can sometimes make you more sensitive to sunlight. If you notice a stronger reaction to sun exposure, it's wise to take protective measures. This includes wearing protective clothing, using sunscreen, and avoiding prolonged sun exposure, especially during the sunniest parts of the day.

Are there any dietary restrictions while taking Aralen?

Generally, there are no specific dietary restrictions. However, taking Aralen with food or milk is recommended to help minimize stomach upset. It's always a good idea to maintain a balanced diet and discuss any significant dietary changes with your healthcare provider.

How does Aralen compare to Hydroxychloroquine?

Aralen (Chloroquine) and Hydroxychloroquine are both antimalarial drugs with similar ways they work and similar uses in autoimmune diseases. Hydroxychloroquine is generally considered to have a slightly better safety profile, especially regarding the risk of retinal toxicity. This is why it is often preferred for long-term use in conditions like lupus and rheumatoid arthritis.

Can Aralen be used to treat COVID-19?

While Chloroquine was looked into as a possible treatment for COVID-19 early in the pandemic due to its antiviral properties in lab settings, clinical trials have generally not supported its widespread use as an effective treatment for COVID-19 in humans. Its use for this condition is not part of standard medical practice in Canada.

Glossary

Heme Polymerization
A process where malaria parasites get rid of toxic heme molecules inside red blood cells. Chloroquine stops this process, leading to the death of the parasite.
Immunomodulatory
This describes a substance that can change or regulate your immune system's response, either by making it stronger or calming it down.
Pharmacokinetics
This is the study of how a drug moves through your body, including how it is absorbed, spread, processed, and removed.
Endosomes
These are small, membrane-bound compartments inside cells that help process materials the cell takes in. They often play a role in how viruses enter cells.
Endemic
This refers to a disease or condition that is regularly found among certain people or in a particular country, such as malaria in specific geographical regions.

Important Information

The information provided about Aralen is for general knowledge only and is not meant to be medical advice. It does not replace a professional medical consultation. All treatment decisions, including any potential off-label uses, should be made with the direct supervision of a qualified healthcare provider. We want you to feel empowered in your health journey, but please remember that you assume full responsibility for your health decisions. Our pharmacy offers access to Aralen for individuals seeking convenient and potentially more accessible medication options in Canada. Always consult with your doctor, pharmacist, or another healthcare professional before you start, change, or stop any medication regimen. Your well-being is our priority.


Buying Aralen Online


Can You Buy Aralen in Canada?

Yes, Aralen is available in Canada, provided you have a valid prescription issued by a licensed healthcare provider. To access cost-effective options, you may opt to order Aralen through our online pharmacy.

Why You Can Import Aralen into Canada

Under Health Canada regulations, importing Aralen for personal use is allowed if the quantity is within approved limits and supported by a valid prescription, which our service facilitates. This offers cost-efficient alternatives, including reliable generic options.

How to Get Affordable Aralen Refills

Refilling your Aralen prescription is quick and affordable with our service. Enjoy a 10% discount on every refill by reordering through your account. Our platform makes refills convenient and budget-friendly.

Exclusive Benefits for Customers in Canada

For customers in Canada, we provide tailored solutions to ensure seamless access to Aralen. Our platform fully complies with Health Canada’s import regulations, offering peace of mind while saving you time and money. Take advantage of exclusive shipping discounts and expedited delivery to all major Canadian provinces and cities (Edmonton, Ottawa, Calgary, Toronto, Montreal, Vancouver).


Aralen Connected Conditions

Aralen Connected Conditions

How to Order Aralen | Chloroquine from our Pharmacy

Ordering Aralen | Chloroquine from our online pharmacy is easy and hassle-free. All you need to do is select the desired dosage and quantity of pills above. The cost of the selected pack will update automatically, so you can see the total cost right away. Next, click the Add to Cart button to add the chosen amount to your cart. Feel free to continue browsing for more medications or head straight to the checkout. At the Checkout, complete the payment process using our secure and dedicated payment gateway, ensuring the safety of your information.

Rest assured, Aralen / Chloroquine pills are made from high-quality generic compounds and undergo strict quality control measures under WHO and Health Products and Food Branch (HPFB) of Health Canada standards. However, Aralen pills are shipped from outside of Canada due to prescriptions being issued overseas. This allows us to provide you with the best value and quality without sacrificing safety or effectiveness.

Disclaimer: The content on this website is meant for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. If you have any health concerns, always consult a qualified healthcare provider. Don’t rely solely on the information here to make medical decisions or delay seeking proper care. This website does not create a doctor-patient relationship. In an emergency, contact local emergency services immediately. We are not responsible for any inaccuracies or missing information in the content provided.

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